Journal: Cells

Article Title: Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28

doi: 10.3390/cells11061006

Figure Lengend Snippet: Upregulation of PIM1 in response to anti-angiogenic agents requires USP28. Mice were injected subcutaneously with PC3-LN4 control or USP28-knockdown cells and treated with a vehicle or sunitinib. ( A ) Growth curve of tumors in the four groups (n = 8). ( B ) Tumors were harvested, and lysates were used for western blotting. Right, quantification. ( C ) Representative immunohistochemical staining of PIM1 in tumors from the four groups (scale bar = 50 μM). Right, quantification. ( D ) Model. * p < 0.05.

Article Snippet: Mice were administered sunitinib (100 mg/kg; Adooq Bioscience, Irvine, CA, USA) or vehicle daily, once the tumors reached ~100 mm 3 ( n = 4 mice and 8 tumors/group).

Techniques: Injection, Control, Knockdown, Western Blot, Immunohistochemical staining, Staining

Journal: Clinical Cancer Research

Article Title: Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy

doi: 10.1158/1078-0432.CCR-21-1129

Figure Lengend Snippet: List of clinical trials evaluating microbiome therapeutics in cancer.

Article Snippet: NCT03637803 (4d Pharma) , Orally bioavailable LBP containing Enterococcus gallinarum flagellin, which has TLR5 stimulatory properties , Select histologies following failure of standard therapy in combination with pembrolizumab (NCT03775850): RCC NSCLC , MRx0518 capsules twice daily. Pembrolizumab per label. , None , Active, not enrolling , Not reported , Not reported.

Techniques: Clinical Proteomics, Capsules, Bacteria, Derivative Assay, Probiotics, Control